RAF Typhoon FGR4s have joined forces with French aircraft in a combined operation targeting an hidden munitions depot in Syrian territory used by the IS group, as stated by the UK Ministry of Defence.
The location, pinpointed through surveillance, was thought to be storing arms and explosives, the statement said, and was positioned in mountainous terrain just above the historic site of Palmyra in Syria's central region.
"Our fighter planes utilized Paveway IV guided bombs to hit a several access tunnels down to the site... early reports indicate the strike was effective," the MoD said.
There was no indication of any civilian casualties in the attack conducted Saturday night and all the aircraft returned safely, the ministry further stated.
The British jets were backed up by a Voyager tanker plane.
Daesh - alternatively referred to as the so-called Islamic State - established militant control over parts of Syria and Iraq prior to its 2019 collapse.
"This strike demonstrates British leadership, and determination to operate in unison with allied nations, to stamp out any revival of Daesh and their dangerous and violent ideologies in the area," Britain's Defence Chief the Defence Secretary remarked.
British military aircraft have performed overwatch operations over Syrian airspace to "prevent any attempted comeback" of the group subsequent to its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I want to thank the personnel of British forces involved in this operation for their skill and their courage," the Defence Secretary commented. "They were among thousands of UK service members deployed over Christmas and New Year. This action, to take out terrorist threats who endanger our way of life, demonstrates how British military are always on standby, all year round, keeping Britain secure domestically and influential overseas."
Last December, the US military carried out what it described as a "massive strike" on Daesh sites in the country, following an attack killed two US troops and a local interpreter in the Palmyra area.
The UN reports IS still maintains between 5,000 and 7,000 fighters in Iraq and Syria.